permaculture

["sals3" <sals3@cox.net>]

you think this Dr. Mae-Wan Ho know what he's talking about. this does not 
seem to be sustainable if this be true. naw the USDA would never let that 
happen.  there seems to be  a lot of GMO out there thanks to the USDA .  on 
a good note
www.non-gmoreport.com   Margaret
Smith at Cornell perfected her new organic corn.  and a 4th generation 
cotton farmer calls for no GMO organic agriculture.
----- Original Message ----- 
From: <press-release@i-sis.org.uk>
To: <sals3@cox.net>
Sent: Monday, June 27, 2011 7:46 AM
Subject: How Genetic Engineering May Have Created E. Coli Outbreak


> The intended recipient for this message is sals3@cox.net
> The Institute of Science in Society
> Science Society Sustainability
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>
> This article can be found on the I-SIS website at
> http://www.i-sis.org.uk/Genetic_Engineering_E_coli_Outbreak.php
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> ISIS Report 27/06/11
>
> How Genetic Engineering May Have Created E. Coli Outbreak
> ################################################
>
> Greatly assisted horizontal gene transfer and recombination turned 
> previously
> harmless bacteria into dangerous pathogens.
> Dr. Mae-Wan Ho
>
> Rapid decoding in the new scientific commons The E. coli O104:H4 genome 
> was
> rapidly decoded within days of the initial outbreak in Germany by Beijing
> Genomics Institute (BGI)'s third generation technologies, and the raw data
> promptly uploaded to a public database
> (ftp://ftp.genomics.org.cn/pub/Ecoli_TY-2482)
> so geneticists all over the world could analyse and annotate the sequences
> and share their findings quickly in a new scientific commons on the 
> internet.
>
> It was clear that the outbreak E. coli O104:H4 is a new strain with a 
> genome
> size of about 5.2 Mbp (million basepairs), which unusually, has both the
> properties of enteroaggregative E. coli (EAEC) that cause diarrhoea and
> enterohaemolytic E. coli (EHEC) that cause haemolytic uremic syndrome 
> (HUS, or
> bloody urine), along with resistance to the widest range of antibiotics 
> [1].
>
> The outbreak strain is most similar to EAEC 55989, previously isolated in 
> the
> Central African Republic from an HIV-positive adult, and since emerged as 
> a
> major cause of diarrhoea in children and adults worldwide [2].  EAEC carry 
> small
> extra units of genetic material called plasmids; the German outbreak 
> strain has
> the typical plasmid genes of EAEC bacteria, as well as the Shiga toxin 
> genes of
> EHEC carried on prophage (genome of bacteria virus) integrated in the 
> bacterial
> chromosome.
>
> Rampant horizontal gene transfer Preliminary analyses using an algorithm 
> that
> searches for protein similarity to define genes based on known proteins in 
> E.
> coli and other bacteria, detected 6327 genes in all, 6156 coding for 
> proteins
> and 171 coding for ribosomal and tRNA.
>
> Of the proteins identified, 33 genes are toxins, 3 suspected haemolysins
> (proteins causing haemolysis), a putative hemolysin expression modulating
> protein, and a channel protein of hemolysin III family. In addition, 31
> predicted genes are related to specific antibiotic resistance: 
> beta-lactamic,
> aminoglycoside, macrolide, polymyxin, tetracycline, fosfomycin and 
> deoxycholate,
> novobiocin, chloramphenicol, bicyclomycin, norfloxacin and enoxacin and 6-
> mercaptopurine [3]. The strain is also rich in adhesion, secretion 
> systems,
> pathogenicity and virulence related proteins. It seems to have a 
> restriction-
> modification system, many proteins involved in Fe transport and 
> utilization
> (siderophores as aerobactin and enterobactin), lysozyme, one inhibitor of
> pancreatic serine proteases, proteins involved in anaerobic respiration,
> antimicrobial peptides, proteins involved in quorum sensing and biofilm
> formation that could confer competitive advantage to the strain. There are 
> genes
> for tellurium resistance and resistance to other metals including mercury,
> nickel, copper, zinc and cobalt, and more than 170 phage proteins.
>
> Read the rest of this report here
> http://www.i-sis.org.uk/Genetic_Engineering_E_coli_Outbreak.php
>
> Or read other articles about biotechnology here
> http://www.i-sis.org.uk/biotechnology.php
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