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  • From: "Tradingpost" <tradingpost@lobo.net>
  • To: livingontheland@lists.ibiblio.org
  • Subject: [Livingontheland] Dehydrated tomatoes show promise for preventing prostate cancer
  • Date: Tue, 03 Jun 2008 12:18:24 -0600


Public release date: 29-May-2008
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Dehydrated tomatoes show promise for preventing prostate cancer
http://www.eurekalert.org/pub_releases/2008-05/aafc-dts052708.php

PHILADELPHIA – New research suggests that the form of tomato product one eats
could be the key to unlocking its prostate cancer-fighting potential,
according to a report in the June 1 issue of Cancer Research, a journal of
the American Association for Cancer Research.

“Processing of many edible plants through heating, grinding, mixing or drying
dramatically increases their nutrition value, including their cancer
prevention potential. It appears that the greatest protective effect from
tomatoes comes by rehydrating tomato powder into tomato paste,” said Valeri
V. Mossine, Ph.D., research assistant professor of biochemistry at the
University of Missouri.

The protective effect of tomato products against prostate cancer has been
suggested in many studies, but researchers remain uncertain about the exact
mechanisms. Mossine and colleagues demonstrated that FruHis, an organic
carbohydrate present in dehydrated tomato products, exerts a strong
protective effect.

Researchers divided rats into groups of 20 and fed them a control diet or a
diet that included tomato paste, tomato powder or tomato paste plus
additional FruHis. All animals were then injected with prostate
cancer-causing chemicals.

Animals fed the tomato paste plus FruHis diet had the longest survival from
cancer at 51 weeks compared with 50 weeks in the tomato powder group, 45
weeks in the tomato paste alone group and 40 weeks in the control group.

On post-mortem exam, prostate tumors were found in 10 percent of the rats
that had been given a combination of tomato paste and FruHis, compared with
30 percent of animals in the tomato powder group, 25 percent in the tomato
paste alone group and 60 percent in the control group.

Mossine said the protective effect of tomato-based products was restricted to
prostate tumors, which is consistent with other research on tomatoes and
cancer. Incidence of other tumors was too small to examine.

In vitro, Mossine and colleagues evaluated the anti-cancer properties of
FruHis and 14 other D-fructose amino acids and found that FruHis in a
concentrated form protected against DNA damage known to lead to prostate
cancer. When combined with lycopene, FruHis stopped cancerous cell growth
more than 98 percent of the time.

“Before this study, researchers attributed the protective effect of tomatoes
to ascorbic acid, carotenoids, or phenolic compounds,” Mossine said. “FruHis
may represent a novel type of potential dietary antioxidant. Experiments like
these suggest that a combination of FruHis and lycopene should be
investigated as a potential therapeutic anti-tumor agent, not just a
prevention strategy.”

Although Mossine cautioned against drawing broad conclusions from this animal
study, he said, “the result may introduce an additional intrigue into an
ongoing dispute over the beneficial effects of dietary lycopene and tomato
products in lowering the risk of prostate cancer. Human trials are certainly
warranted.”




  • [Livingontheland] Dehydrated tomatoes show promise for preventing prostate cancer, Tradingpost, 06/03/2008

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