[permaculture] Fwd: [SANET-MG] glyphosate toxic to humans at a 450-fold dilution of spraying used in agriculture

Lawrence F. London, Jr. lflj at bellsouth.net
Sat Mar 10 15:49:42 EST 2012


-------- Original Message --------
Subject: [SANET-MG] glyphosate toxic to humans at a 450-fold dilution of 
spraying used in agriculture
Date: Sat, 10 Mar 2012 15:10:27 -0500
From: jcummins <jcummins at UWO.CA>
To: SANET-MG at LISTS.IFAS.UFL.EDU

Glyphosate has proven to be genotoxic to people such findings should not 
be ignored by regulators in USA, Canada and EU
Arch Toxicol. 2012 Feb 14. [Epub ahead of print]
Cytotoxic and DNA-damaging properties of glyphosate and Roundup in
human-derived buccal epithelial cells.
Koller VJ, Fürhacker M, Nersesyan A, Mišík M,
Eisenbauer M, Knasmueller S.
Abstract
Glyphosate (G) is the largest selling herbicide worldwide; the most
common formulations (Roundup, R) contain polyoxyethyleneamine as main
surfactant. Recent findings indicate that G exposure may cause DNA
damage and cancer in humans. Aim of this investigation was to study the
cytotoxic and genotoxic properties of G and R (UltraMax) in a buccal
epithelial cell line (TR146), as workers are exposed via inhalation to
the herbicide. R induced acute cytotoxic effects at concentrations >40
mg/l after 20 min, which were due to membrane damage and impairment of
mitochondrial functions. With G, increased release of extracellular
lactate dehydrogenase indicative for membrane damage was observed at
doses >80 mg/l. Both G and R induced DNA migration in single-cell gel
electrophoresis assays at doses >20 mg/l. Furthermore, an increase of
nuclear aberrations that reflect DNA damage was observed. The
frequencies of micronuclei and nuclear buds were elevated after 20-min
exposure to 10-20 mg/l, while nucleoplasmatic bridges were only enhanced 
by R at the highest dose (20 mg/l). R was under all conditions more 
active than its active principle (G). Comparisons with results of
earlier studies with lymphocytes and cells from internal organs indicate
that epithelial cells are more susceptible to the cytotoxic and
DNA-damaging properties of the herbicide and its formulation. Since we
found genotoxic effects after short exposure to concentrations that
correspond to a 450-fold dilution of spraying used in agriculture, our
findings indicate that inhalation may cause DNA damage in exposed
individuals.




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