[permaculture] Fwd: [SANET-MG] The Failure of the Genome
soildoctor.org at gmail.com
Sun May 1 13:45:38 EDT 2011
The current scientific inventory of genetic material in the human body puts the amount of human genetic material at a mere 0.7%. 99.3% is microbial and non-human. Metagenomics and metabolomics are popping the top off of the interactions between a human host and microbes and showing that in most human diseases and processes there is a microbial connection. A couple of months ago researchers published a paper showing guy microbes regulated human liver function, for one small example. Studying ONLY the human genetic material is like looking only at how a door handle is built in order to understand how a full house was constructed. I've made a few recent posts about the paradigm change occurring in medical sciences because there is greater understanding (through metagenomics and metabolomics) of human-microbial symbiosis and mutualism. Generally, the edge medical science is changing its treatment paradigm from "antibiotic" to "probiotic." I wrote about this on my soil blog because it mirrors what a lot of us are doing in regenerative microbiological agriculture. In case you're interested to hear from the researchers here's a couple of posts:
> Message: 2
> Date: Fri, 29 Apr 2011 11:38:22 -0600
> From: Toby Hemenway <toby at patternliteracy.com>
> Subject: Re: [permaculture] Fwd: [SANET-MG] The Failure of the Genome
> To: permaculture <permaculture at lists.ibiblio.org>
> Message-ID: <818C7745-515B-49F8-96D5-5A3543593B3B at patternliteracy.com>
> Content-Type: text/plain; charset=us-ascii
> This article takes the typical journalist "gotta get a controversial angle" stance and gets a lot of it wrong. For example,
> "The human genome sequencing project was based on a huge, but calculated, gamble. The then leaders-to-be of the project believed that faulty genes inherited from our parents were probably the cause of most disease."
> But then they quote the leader of the federal genome project who agrees that there have been no significant cures. And the leader of the private project, Craig Venter, always said it was more for the sake of doing it, to see the patterns that reside in the genome, rather than to find cures. Every geneticist I worked with for years understood that the correlation between any single gene and a disease was going to be very murky. But the power of DNA sequencing tools is immense, and is rewriting botanical taxonomy and evolutionary relationships, among many other things, even if the practical payoff, in terms of products and cures, is never going to amount to much. What we're learning about the patterns of inheritance and evolution is enormous.
> On Apr 28, 2011, at 6:17 PM, Lawrence F. London, Jr. wrote:
>> -------- Original Message --------
>> Subject: [SANET-MG] The Failure of the Genome
>> Date: Thu, 28 Apr 2011 12:40:55 -0400
>> From: jonathan latham <jrlatham at BIOSCIENCERESOURCE.ORG>
>> To: SANET-MG at LISTS.IFAS.UFL.EDU
>> This may look like it's not relevant to you but sustainable farmers,
>> processors, supporters and researchers need to know about this and
>> they need their customers, their funders, their friends and their
>> neighbours to know about it too.
>> As one of the comments notes, medical genetics got its start from the
>> tobacco industry, and its second wind from the food and
>> pharmaceutical industries. They know how to tilt the playing field.
>> Sustainable farmers now have a chance to tilt it back. Send this to
>> everyone you know (and every listserv you know).
>> Jonathan Latham (PhD)
>> Executive Director
>> The Bioscience Resource Project
>> jrlatham at bioscienceresource.org
>> PO Box 6869
>> Suite 132, 215 N. Cayuga St.
>> Ithaca 14851 NY
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