Permaculturist Health

[Lawrence London <lfljvenaura@gmail.com>]

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pchealth

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High-fiber diet keeps gut microbes from eating the colon's lining, protects against infection, animal study shows

Date:

November 17, 2016

Source:

University of Michigan Health System

Summary:

When microbes inside the digestive system don't get the natural fiber that they rely on for food, they begin to munch on the natural layer of mucus that lines the gut, eroding it to the point where dangerous invading bacteria can infect the colon wall, new research in mice shows.

https://www.sciencedaily.com/releases/2016/11/161117134626.htm

* * * *

Mahesh S. Desai et al. 
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility. 
Cell, November 2016
http://www.cell.com/cell/abstract/S0092-8674(16)31464-7

Summary

Despite the accepted health benefits of consuming dietary fiber, little is known about the mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk. Using a gnotobiotic mouse model, in which animals were colonized with a synthetic human gut microbiota composed of fully sequenced commensal bacteria, we elucidated the functional interactions between dietary fiber, the gut microbiota, and the colonic mucus barrier, which serves as a primary defense against enteric pathogens. We show that during chronic or intermittent dietary fiber deficiency, the gut microbiota resorts to host-secreted mucus glycoproteins as a nutrient source, leading to erosion of the colonic mucus barrier. Dietary fiber deprivation, together with a fiber-deprived, mucus-eroding microbiota, promotes greater epithelial access and lethal colitis by the mucosal pathogen, Citrobacter rodentium. Our work reveals intricate pathways linking diet, the gut microbiome, and intestinal barrier dysfunction, which could be exploited to improve health using dietary therapeutics.

______________________________

Jonathan Latham, PhD
Executive Director

The Bioscience Resource Project

Ithaca, NY 14850 USA

www.independentsciencenews.org
and
www.bioscienceresource.org

jrla...@bioscienceresource.org
Skype: jonathanlatham2
Tel: 1-607-319-0279

“The conscious and intelligent manipulation of the organized habits and opinions of the masses is an important element in democratic society. Those who manipulate this unseen mechanism of society constitute an invisible government which is the true ruling power of our country.”—Edward Bernays, Propaganda

--

Lawrence F. London, Jr.
lfljvenaura@gmail.com

https://sites.google.com/site/avantgeared