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  • From: "sals3" <sals3@cox.net>
  • To: "permaculture" <permaculture@lists.ibiblio.org>, "Sustainable Agriculture Network Discussion Group" <SANET-MG@LISTS.IFAS.UFL.EDU>, "Organic Gardening Discussion List" <OGL@LSV.UKY.EDU>
  • Subject: [permaculture] Fw: How Genetic Engineering May Have Created E. Coli Outbreak
  • Date: Mon, 27 Jun 2011 09:45:08 -0700

you think this Dr. Mae-Wan Ho know what he's talking about. this does not seem to be sustainable if this be true. naw the USDA would never let that happen. there seems to be a lot of GMO out there thanks to the USDA . on a good note
www.non-gmoreport.com Margaret
Smith at Cornell perfected her new organic corn. and a 4th generation cotton farmer calls for no GMO organic agriculture.
----- Original Message ----- From: <press-release@i-sis.org.uk>
To: <sals3@cox.net>
Sent: Monday, June 27, 2011 7:46 AM
Subject: How Genetic Engineering May Have Created E. Coli Outbreak


The intended recipient for this message is sals3@cox.net
The Institute of Science in Society
Science Society Sustainability
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This article can be found on the I-SIS website at
http://www.i-sis.org.uk/Genetic_Engineering_E_coli_Outbreak.php

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========================================================
ISIS Report 27/06/11

How Genetic Engineering May Have Created E. Coli Outbreak
################################################

Greatly assisted horizontal gene transfer and recombination turned previously
harmless bacteria into dangerous pathogens.
Dr. Mae-Wan Ho

Rapid decoding in the new scientific commons The E. coli O104:H4 genome was
rapidly decoded within days of the initial outbreak in Germany by Beijing
Genomics Institute (BGI)'s third generation technologies, and the raw data
promptly uploaded to a public database
(ftp://ftp.genomics.org.cn/pub/Ecoli_TY-2482)
so geneticists all over the world could analyse and annotate the sequences
and share their findings quickly in a new scientific commons on the internet.

It was clear that the outbreak E. coli O104:H4 is a new strain with a genome
size of about 5.2 Mbp (million basepairs), which unusually, has both the
properties of enteroaggregative E. coli (EAEC) that cause diarrhoea and
enterohaemolytic E. coli (EHEC) that cause haemolytic uremic syndrome (HUS, or
bloody urine), along with resistance to the widest range of antibiotics [1].

The outbreak strain is most similar to EAEC 55989, previously isolated in the
Central African Republic from an HIV-positive adult, and since emerged as a
major cause of diarrhoea in children and adults worldwide [2]. EAEC carry small
extra units of genetic material called plasmids; the German outbreak strain has
the typical plasmid genes of EAEC bacteria, as well as the Shiga toxin genes of
EHEC carried on prophage (genome of bacteria virus) integrated in the bacterial
chromosome.

Rampant horizontal gene transfer Preliminary analyses using an algorithm that
searches for protein similarity to define genes based on known proteins in E.
coli and other bacteria, detected 6327 genes in all, 6156 coding for proteins
and 171 coding for ribosomal and tRNA.

Of the proteins identified, 33 genes are toxins, 3 suspected haemolysins
(proteins causing haemolysis), a putative hemolysin expression modulating
protein, and a channel protein of hemolysin III family. In addition, 31
predicted genes are related to specific antibiotic resistance: beta-lactamic,
aminoglycoside, macrolide, polymyxin, tetracycline, fosfomycin and deoxycholate,
novobiocin, chloramphenicol, bicyclomycin, norfloxacin and enoxacin and 6-
mercaptopurine [3]. The strain is also rich in adhesion, secretion systems,
pathogenicity and virulence related proteins. It seems to have a restriction-
modification system, many proteins involved in Fe transport and utilization
(siderophores as aerobactin and enterobactin), lysozyme, one inhibitor of
pancreatic serine proteases, proteins involved in anaerobic respiration,
antimicrobial peptides, proteins involved in quorum sensing and biofilm
formation that could confer competitive advantage to the strain. There are genes
for tellurium resistance and resistance to other metals including mercury,
nickel, copper, zinc and cobalt, and more than 170 phage proteins.

Read the rest of this report here
http://www.i-sis.org.uk/Genetic_Engineering_E_coli_Outbreak.php

Or read other articles about biotechnology here
http://www.i-sis.org.uk/biotechnology.php
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  • [permaculture] Fw: How Genetic Engineering May Have Created E. Coli Outbreak, sals3, 06/27/2011

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