You didn't say what you intended to grow on your farm and how many acres of it. You need to know about legal ramifications in your state- for that contact your states DEC. As far as what you can do about drift, if you are only planning on growing a couple acres of fruit of so you can always use a high pressure sprayer with a gun instead of a mist mist sprayer which would reduce drift considerably. Also the smaller the trees the easier to control, of course, and there are adjuvents to reduce drift. A densely grown hedge on highway side would serve two purposes- hiding what you are doing and reducing drift.
It could be quite a boon to have that location if you intend to sell your produce as you've probably already calculated.
[NAFEX] Jerry's spray drift question,
Alan Haigh, 09/16/2009