You said women don't have descendants in the Bible, but in Genesis 16:10, the
angel talks about Hagar's seed. Would you call that descendants of a woman?
There are more quotes like that.
Also, when was Jacob ruler over Esau like the blessing said? Do you think
Isaac was saying that Esau (or disguised Jacob) would only rule his actual
brothers and not their descendants too? Later in Gen 27 he said Esau would
break the yoke of his brother off of him, but when did Jacob have a yoke on
him?