[permaculture] Fwd: Grass Plants Bind, Retain, Uptake, and Transport Infectious Prions: Cell Reports

Lawrence London lfljvenaura at gmail.com
Mon May 18 15:46:11 EDT 2015


Grass Plants Bind, Retain, Uptake, and Transport Infectious Prions: Cell
Reports
http://www.cell.com/cell-reports/abstract/S2211-1247%2815%2900437-4?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124715004374%3Fshowall%3Dtrue

Grass Plants Bind, Retain, Uptake, and Transport Infectious Prions
Sandra Pritzkow
,
Rodrigo Morales
,
Fabio Moda3
,
Uffaf Khan
,
Glenn C. Telling
,
Edward Hoover
,
Claudio Soto[image: correspondence][image: email] <claudio.soto at uth.tmc.edu>
3Present address: IRCCS Foundation Carlo Besta Neurological Institute,
20133 Milan, Italy
Publication stage: In Press Corrected Proof
Open Access
DOI: http://dx.doi.org/10.1016/j.celrep.2015.04.036

Open access funded by the Author(s)
[image: show]Article Info
<http://www.cell.com/cell-reports/abstract/S2211-1247%2815%2900437-4?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124715004374%3Fshowall%3Dtrue#>
Highlights

   - •Grass plants bind prions from contaminated brain and excreta
   - •Prions from different strains and species remain bound to living
   plants
   - •Hamsters fed with prion-contaminated plant samples develop prion
   disease
   - •Stems and leaves from grass plants grown in infected soil contain
   prions

Summary

Prions are the protein-based infectious agents responsible for prion
diseases. Environmental prion contamination has been implicated in disease
transmission. Here, we analyzed the binding and retention of infectious
prion protein (PrPSc) to plants. Small quantities of PrPSc contained in
diluted brain homogenate or in excretory materials (urine and feces) can
bind to wheat grass roots and leaves. Wild-type hamsters were efficiently
infected by ingestion of prion-contaminated plants. The prion-plant
interaction occurs with prions from diverse origins, including chronic
wasting disease. Furthermore, leaves contaminated by spraying with a
prion-containing preparation retained PrPSc for several weeks in the living
plant. Finally, plants can uptake prions from contaminated soil and
transport them to aerial parts of the plant (stem and leaves). These
findings demonstrate that plants can efficiently bind infectious prions and
act as carriers of infectivity, suggesting a possible role of environmental
prion contamination in the horizontal transmission of the disease.

This is an open access article under the CC BY license (
http://creativecommons.org/licenses/by/4.0/).
Received: October 31, 2014; Received in revised form: February 4,
2015; Accepted:
April 15, 2015; Published Online: May 14, 2015
© 2015 The Authors. Published by Elsevier Inc.



-- 
Lawrence F. London
lfljvenaura at gmail.com
Ello: @ecoponderosa <https://ello.co/ecoponderosa>
https://sites.google.com/site/avantgeared/
https://sites.google.com/site/venaurafarm/


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